There is no one definitive answer to this question, as the best way to farm crystalline ore in GW2 will vary depending on the specific location and conditions of the mine. However, some tips on how to farm crystalline ore in GW2 include using a pickaxe or a shovel to break through the rock, using a minecart or boat to transport ore from one spot to another, and using a cart or wagon to carry ore back and forth between two spots.